After the daughter of Wang Wei (Xie Miao) is kidnapped by a criminal network and he receives no help from the corrupt police, Wei sets out on a rampage to find her himself. His only ally is Navin (Joe Taslim) - a relentless journalist whose wife has mysteriously disappeared. Fueled by a furious vengeance, the unlikely duo ruthlessly fights against the kidnappers in this explosive martial arts s...

For første gang i Spider-Mans filmiske historie afsløres vores venlige lokale helt og er ikke længere i stand til at adskille sit normale liv fra den store risiko af at være en superhelt. Da han beder om hjælp fra Doctor Strange, bliver indsatsen endnu farligere, hvilket tvinger ham til at opdage, hvad det virkelig betyder at være Spider-Man.