Sex complicates things, and sex with your best friend - even more complicated. When you add into the mix a sex crazed therapist, creepy high school teachers, a dominatrix, and a kind, but duplicitous, filmmaker - your whole life can go off the rails...in a most comedic way. Kathy Griffin, Ryan Stiles, Taylor Negron, Chris Hardwick, Dana Gould and Ana Gasteyer help round out the ensemble cast.