A by-the-book policewoman is assigned to protect the wise-cracking wife of a witness who is about to testify against his drug lord boss but are forced to go on the run to hide from assassins and corrupt cops while traveling through Texas.

Washed-up revolutionary Bob (Leonardo DiCaprio) exists in a state of stoned paranoia, surviving off-grid with his spirited, self-reliant daughter, Willa (Chase Infiniti). When his evil nemesis (Sean Penn) resurfaces after 16 years and she goes missing, the former radical scrambles to find her, father and daughter both battling the consequences of his past.