I en klasse meldes alle undtagen ét barn savnet, og alle undrer sig over, hvem eller hvad der står bag deres forsvinden.

Illumination expands its joyful Minions universe with a riotous chapter featuring all-new characters in the biggest global animated franchise in history. This is the rambunctious, ridiculous and totally true story of how the Minions conquered Hollywood as movie stars, lost everything, unleashed monsters onto the world and then banded together to try saving the planet from the mayhem they created.