Extreme Makeover Weight Loss Edition

Chris helps a man whose struggle with weight has left him jobless.

A 355-pound woman works to lose weight.

Michael is a 28-year-old small-business consultant who weighs 493 pounds.

Ashley tries to lose half of her 323 pounds by her 21st birthday.

A 435-pound woman struggles with the commitment needed to get healthy.

A 543-pound man works to get healthy so he can be a better father, husband.

A 45-year-old mother tries to slim down and get healthy.

A newlywed from Portland, wants to lose 50 percent of his body weight.