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A string of brutal murders brings will graham back to the FBI and begins his relationship with dr. Hannibal Lecter

Will and Jack hunt a killer who is burying his victims alive, so they will become fertilizer for his garden of fungus. While the tabloid journalist Freddie sets targets in on Will.

Determined to give Abigail closure, Will and Hannibal take Abigail back to the scene of her father's crimes. But things take a turn for the worse when the copycat killer strikes again.

A series of family murders takes place, and Will determines they were conducted by each of the families' missing children, who were abducted and brainwashed into killing their old families for their "new family."

A murdered couple is found in a motel room, posed in praying positions with the flesh of their backs opened and strung to the ceiling to give them the appearance of wings.

A nurse at a state hospital for the criminally insane is murdered by a patient, Dr. Abel Gideon, in a manner reminiscent of the "Chesapeake Ripper", who hasn't committed a murder in two years, the same number of years Gideon has been incarcerated.

Will has nightmares of himself as a killer while Hannibal sees a therapist of his own and begins his seduction of Alana.

Lecter's patient Franklin Froideveaux worries that his friend Tobias may be a psychopath, but Franklin's growing obsession with Lecter is what concerns the latter more.

幾つもの死体を積み重ねた“トーテムポール”が発見される。現場に入ったウィルは早速見立てを始める…が、気がつくとハンニバルの部屋に立っていた。追いつめられた心が、解離症状を引き起こしたのだ。

Beth LeBeau is found murdered, having drowned in her own blood as a result of her face being cut into a Glasgow smile. Graham's mental state continues to sharply decline.

Dr. Abel Gideon escapes from custody and begins targeting the psychiatrists who attempted to treat him, displaying their bodies with a Colombian necktie. Graham's undiagnosed Encephalitis drives his temperature up, causing severe hallucinations.

Graham deduces that several recent murders were all the work of a copycat patterning after recent serial murders, and that Georgia was killed because she may have remembered the face of whoever had killed Dr. Sutcliffe.

Will's mental decline results in tragedy, when it appears he may have murdered Abigail Hobbs. With himself as his only defender, Will desperately tries to prove he's being framed by the real Copy Cat killer.