Most Extreme Humans

Mark's hands are 20 times bigger than a normal adult male's. After learning that his condition may require amputation, Mark stopped seeing doctors. Now troubling changes to his hands means he must go back. If not for himself, then for his young daughter.

Winner of the Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured. With 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

In Brazil, Claudio lives with a condition that bent his head backward. Ahead of his 50th birthday, he wants to climb a sacred mountain. In Norway, Birgitte lives with a different presentation of the same condition. She's training for the next Paralympics.

Life defined by height: in Turkey, the world's tallest woman lives with an unknown genetic condition linked to extreme growth and fragile bones, while in Brazil, the world's shortest couple navigate dwarfism and its physical challenges.

Milagros lives with tumors so heavy that her face droops down to her torso. After hiding away, a health scare is forcing her out into the world. Twenty-one-year-old Lizzie is preparing to live independently even after tumors have grown over her eyes.

In rural Indian, Lalit's face and body have been thickly covered in hair since the day he was born. Doctors theorized that the hair would fall out once he reached peak maturity. Now that he's turning 20, Lalit seeks out a specialist to learn his fate.

Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions. Mahfuza prepares for her first boxing match. Nelly fully supports her friend but worries that the high risks may outweigh the rewards.

Summer has macromastia, a condition that causes her breasts to keep growing. With constant pain in her back and neck from breasts that are now a third of her overall body weight, Summer travels from Scotland to Los Angeles looking for answers.

Ecuadorian conjoined twins Jose Luis and Jose Armando leave their home and family to get advanced medical care for a chance at independence. Teenaged Thai conjoined twins Pin and Pan must navigate their ongoing differences as they prepare for adulthood. 

In Indonesia, Dimas dreams of becoming a martial arts warrior, but his family worries the training will harm his oddly bendy body. In Colombia, Herson's backward-bending knees are failing. Now he's questioning his dream of proposing to his girlfriend.