On their last night before embarking on separate life paths, best friends Jo and Raissa find a mysterious portal that transports them to Nakali, a mythical island filled with magical creatures they learned about from their Filipino families. As Jo and Raissa search for a way home, they discover their memories are at risk. Will they find a way off the island before they forget each other forever?

シーズン2・リストの完遂後、次の生きる目的を探すジェームズ・リースは、謎の勢力によってモスクワからラングレーにまたがる世界的な陰謀に巻き込まれていく。