When several prostitutes turn up dead near the Genessee River, Rochester police conclude they’re facing a serial killer. Investigators discover that the perpetrator returns to the bodies after the kill. Can they catch him before he strikes again?

Women are mysteriously disappearing from the streets of Philadelphia. Then Josefina Rivera, a prostitute who’s been missing, tells police that she’s been held captive in the basement of a madman. Police descend on the house and make a shocking discovery.

When teenager Lynette Ledford is found naked a strangled to death, Los Angles police determine they’re dealing with two sexually motivated killers. Police then uncover the suspects’ van and find chilling evidence of the killers’ reign of terror.

New Jersey police investigating a series of mob murders discover the victims are connected to one man, a coldblooded killer named Richard Kuklinski. Can undercover agent Dominick Parlifone infiltrate Kuklinski’s circle and bring him to justice?

Police are shocked when Savannah local Milton Bradley is found brutally murdered. They soon discover he’s the victim of a ruthless killer who preys on gay men. The FBI must track this transient hustler and catch him before he strikes again.

When healthy patients in New Jersey hospitals die of mysterious causes doctors are baffled. An investigation reveals they were victims of a sinister poisoning spree. Officials hone in on a hospital employee with a questionable record and a troubled past.

Police rush to the home of Raman Salcido, a suspected spree killer whose marriage is crumbling. There they find Ramon’s wife dead and the couple’s three daughters missing. Can police track down Ramon and the girls before it’s too late?

Anna Hopkins tells police that her 23-year-old daughter has vanished after a night at a local bar. Patrons report that she left with an unidentified man. Hopkins takes matters into her own hands, staking out the bar in hopes that the man will return.

When Carol Hilley reveals that her mother, Marie, has been secretly injecting her with poison, Marie is arrested for attempted murder. After posting bail, Marie vanishes. Can police track down this manipulative killer before she strikes again?

A young man franticly tells police that he's escaped from the house of a torturous madman named Bob. Police storm the house and discover a horrifying torture chamber. Investigators suspect Bob of murder but must discover where he has buried the bodies.

When 23-year-old Laura Houghteling goes missing, police suspect the family gardener, an eccentric man with a history of cross-dressing. Laura’s mother believes he’s innocent but when investigators search his storage shed they make a shocking discovery.

When an intruder bursts into Melinda Aguilar’s apartment she fears the worst. But Aguilar miraculously frees herself and calls for help. When police arrest the intruder and run his background, they suspect he’s behind a vicious multi-state murder spree.