Excited about her speedy new horse, a gift from the Cheyenne, Dr. Mike tries to enter a high-stakes race, but the rules committee turns her away because she lacks one important qualification--she's not a man.

It is up to Dr. Mike to use medical evidence to prove that Loren's sister-in-law, Dorothy Jennings, did not murder her abusive husband.

Everyone is spooked by a mysterious "dead man" (Tom Poston), who keeps disappearing and then reappearing somewhere else in town on Halloween.

When the Cheyenne brave Little Eagle is found dead, Jake is blamed, putting the entire town at odds over the incident.

An overbearing faith healer (June Carter Cash) clashes with Dr. Mike over treatment for the deteriorating health of Kid Cole (Johnny Cash), who has tuberculosis.

When Dr. Mike receives word that her mother (Georgann Johnson) is in the hospital, she goes home to Boston with her children and makes her own diagnosis, which shocks the medical community and impresses young Doctor William Burke (Edward Albert), on part one of a two part episode.

When Dr. Mike receives word that her mother (Georgann Johnson) is in the hospital, she goes home to Boston with her children and makes her own diagnosis, which shocks the medical community and impresses young Doctor William Burke (Edward Albert), on part two of a two part episode.

Although Dr. Mike thinks the Cheyenne can help the townspeople survive a severe drought, Jake and Loren's suspicions and prejudices jeopardize everyone's Thanksgiving.

The Sweethearts Dance is approaching and love is in the air, but Dr. Mike becomes suspicious when Sully is seen with Dorothy. Meanwhile, Colleen is torn by her feelings for the boy her best friend likes.

When Sully is shot by the Cavalry in its battle against the Dog Soldiers, and a price is put on his head, the children hide him.

On Christmas Eve, Dr. Mike is tending to a young pregnant woman and during her long labor, she is visited by the spirit of an old friend, Charlotte Cooper, who helps her reexamine her life and the choices she's made.

Matthew starts a new mining job to build a future, but a cave-in could cost him his life unless Sully can save him.

After Dr. Mike and Sully convince the Cheyenne to accept the government's offer of blankets and supplies, she and Sully are soon helping to save the Cheyenne from a deadly virus they feel responsible for delivering.

A woman named Heart comes to town with her traveling circus and her daughter, Atlantis, who feels like an outcast until Matthew helps her.

A white woman who has adopted Indian ways grows increasingly fond of Sully and comes between him and Dr. Mike.

When Dr. Mike spends time with the Reverend helping orphans find families, he develops an interest in adopting children of his own -- and in marrying her -- while her own children begin to feel neglected.

When a cavalry of Black troops - the Buffalo Soldiers - arrives to confront the renegade Indians, Sully and Dr. Mike pose as scouts to gain information and prevent further bloodshed.

Matthew discovers the rewards of gambling from a slick teacher and believes he's found an easy way to make money, until Dr. Mike and Sully remind him how quickly he can lose everything.

When Dorothy's son, Tom, returns home with an injury and seeks treatment from Dr. Mike, he hides a shameful secret -- an addiction to morphine.

When Denver banker Jedediah Bancroft (George Furth) returns to Colorado Springs to sell homes, he is accompanied by the Ku Klux Klan who are seeking new members to spread their message and try to force one Black homeowner - Robert E. - to move out.

The Reverend's good friend, Louise, becomes the new school teacher and Dr. Mike's new friend, but when some of the school children seek medical treatment, Dr. Mike suspects that her well-liked friend may be abusing them.

Michaela's intervention between the renegade Indian Dog Soldiers and Custer's Army gets her kidnapped, and Sully must find her before she is killed, on part one of a two part episode.

Michaela's intervention between the renegade Indian Dog Soldiers and Custer's Army gets her kidnapped, and Sully must find her before she is killed, on part two of a two part episode.

Jake Slicker's unexpected political opponent in the election for mayor is a surprise - and a woman - Dr. Quinn.