Nancy and Dan take a deeper look at the trial of Casey Anthony, a woman who was found not guilty of murdering her daughter in 2011. The trial's presiding judge, Belvin Perry, as well as an alternate juror and Casey's former cellmate offer added insight.

Nancy and Dan take a new look the disappearance of Stacy Peterson as they interview Joel Brodsky, the former defense attorney for her husband, Drew Peterson. They also speak to Stacy's pastor and Drew's second wife, Vicki Connolly.

Nancy and Dan reexamine the unsolved murder of Chandra Levy. Ingmar Guandique was convicted of her murder but was granted a new trial when it was discovered that a witness lied during testimony.

Nancy and Dan take a new look at the unsolved murder of actor Robert Blake's wife, Bonnie Lee Bakley. Blake was tried and acquitted for her murder but found liable for her death in a civil trial and ordered to pay her children millions.

Nancy and Dan join the debate over the case of Adnan Syed, a man convicted for the murder and kidnapping of his former girlfriend, Hae Min Lee, until his conviction was vacated in 2018.

Nancy and Dan take a fresh look at the death of Laci Peterson, whose husband Scott was convicted of her murder in 2004 and is currently spending life in prison without the possibility of parole.