Inspired by a real medical director's experience at the oldest public hospital in America, this emotionally gripping medical drama follows the brilliant and charming Dr. Max Goodwin (Ryan Eggold), as he sets out to change a broken system and provide exceptional care to the people who need it most.

Max navigates his diagnosis while Dr. Sharpe encourages him to make a plan. Meanwhile, Dr. Bloom encourages Reynolds to take a chance and Dr. Kapoor and Iggy work together to help a child.

Reynolds begins to build his department as Dr. Sharpe battles skepticism from a patient's parents. Meanwhile, Max helps Bloom find a solution for a pregnant patient in a tough spot, all the while continuing to avoid the reality of his diagnosis.

When Max volunteers New Amsterdam to take over for a short-staffed hospital nearby, things get chaotic quickly. Iggy has a crisis of conscience after receiving the news that funding for a garden has been granted and an eager resident learns a secret about Dr. Bloom.

A journalist visits New Amsterdam to shadow Max (Ryan Eggold) and learn about the hospital. Bloom (Janet Montgomery) and Reynolds (Jocko Sims) have a major disagreement after she makes a call against protocol and Kapoor (Anupam Kher) deals with issues from his past.

The pressure is on as Max takes on his first annual fundraising gala at the hospital and emotions are high as some of the doctor's families join them for the event. Iggy struggles to break difficult news to his daughter and Bloom and Reynolds continue to deal with the fallout of their argument. Meanwhile, Kapoor and Dr. Sharpe work together to find out what is making a father and son duo so sick.

The Midnighters join forces to protect a newcomer in town. With Bobo still in danger, Fiji's forced to take desperate action to save him. Patience and Manfred bond over their relationship troubles.

A patient's treatment plan takes an unexpected turn when Max (Ryan Eggold) gets overly invested. Meanwhile, Reynolds (Jocko Sims) celebrates his birthday with some help from the hospital and Kapoor (Anupam Kher) grapples with a case that hits close to home.

Max (Ryan Eggold) convinces Dr. Sharpe (Freema Agyeman) to take a risk on his course of treatment and Bloom (Janet Montgomery) grapples with a difficult conversation. Meanwhile, Dr. Kapoor (Anupam Kher) considers helping his son in a big way after some advice from a friend.

As Max (Ryan Eggold) fights for his life, New Amsterdam is in full swing with a pertinent heart surgery that is not covered by insurance and a potential nurses walk out. As the team feels Max's absence and the doctors find out that they may have to treat one of their own, Sharpe (Freema Agyeman) must finally come clean about Max's condition.

As Max (Ryan Eggold) begins his treatment, he realizes that it may slow him down faster than he originally thought. Meanwhile, Reynolds (Jocko Sims) must deal with an incident from his past when a reporter comes to the hospital and Sharpe (Freema Agyeman) and Bloom (Janet Montgomery) continue a contentious conversation.

Tensions are high in the hospital as Bloom (Janet Montgomery) is overruled on a diagnosis. Meanwhile, Iggy (Tyler Labine) notices that something may be amiss with one of the hospital's most respected surgeons.

Max (Ryan Eggold) continues to work to solve underlying problems within the hospital despite his continuing struggles with treatment. Meanwhile, Reynolds (Jocko Sims) makes the choice to do a costly surgery to determine an elusive diagnosis and Bloom (Janet Montgomery) must face her personal demons head-on.

Sharpe (Freema Agyeman) struggles when a case hits too close to home and Iggy (Tyler Labine) uncovers a patient's surprising past. Meanwhile, Floyd (Jocko Sims) makes progress in his personal life after some difficult news.

Max (Ryan Eggold) bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality. Meanwhile, Reynolds (Jocko Sims) has difficulty handling a personal matter regarding a patient's family and Iggy (Tyler Labine) struggles with a realization regarding his daughter.

When a history-making blizzard hits New York, Max (Ryan Eggold) and his staff must work together to keep their patients safe with little resources, even if it means taking to the streets of the city and braving the storm.

As the doctors continue to weather the storm without power, Max (Ryan Eggold) relies on an unlikely source to get the lights back on. Meanwhile, Reynolds (Jocko Sims) must get creative as he continues to work to save Hugh with very few resources.

Reynolds (Jocko Sims) struggles to help a young Cystic Fibrosis patient (Guest Star Lilly Knowles) with curious symptoms while Kapoor (Anupam Kher) finally comes face to face with Ella (Guest Star Dierdre Friel) after their awkward encounter. Meanwhile, Sharpe (Freema Agyeman) takes a major step in her personal life.

When a NYPD officer is hit by a car in the line of duty, the hospital is turn upside down trying to save her. Meanwhile, Kapoor (Anupam Kher) and Iggy (Tyler Labine) work with a patient struggling with a previous surgery.

Max (Ryan Eggold) is forced to reckon with his diagnosis in a new way as things become more difficult for him. Meanwhile, Reynolds (Jocko Sims) is forced to address what could have gone wrong in a recent surgery.

Max (Ryan Eggold) goes head to head with hospital administration when he comes up with a new plan for patients without insurance. Meanwhile, Iggy (Tyler Labine) struggles with an accusation brought against him and Sharpe (Freema Agyeman) navigates her role as Deputy Medical Director.

In the Season One finale, Sharpe (Freema Agyeman) works on a creative way to help Max (Ryan Eggold) and Kapoor (Anupam Kher) gets surprising news. Meanwhile, Reynolds (Jocko Sims) takes a big step in his relationship with Evie (Guest Star Margot Bingham) as one of the doctors makes a life altering decision.