When a vivacious, young escort, Shannan Gilbert, vanishes on Long Island in 2010, her disappearance leads police to discover the bodies of 10 other victims buried by a serial killer.

The discovery of the bodies of four women in Gilgo, New York, is just the beginning. Investigators uncover multiple suspects and shocking theories as they race to capture a prolific killer before he strikes again.

In 2011, a 10-month-old baby girl goes missing from her home in Kansas City, Missouri. The family fears she has been kidnapped by a drifter, only to be accused by the police for being responsible

In 1991, Jackie Galloway is found strangled and bound with ritualistic knots. Police investigate suspects, but are shocked when a chance encounter with a prowler leads them to discover the murderer is a budding serial killer.

In 1981, a mother and three teens are murdered in Keddie, California. Despite a trail of suspects, no one is ever brought to justice. However, recently discovered evidence may be the key to finally cracking the case.

In 2012, hikers in the Hollywood Hills, California, discover the severed head of Hervey Medellin, a retired flight clerk. The cast of suspects includes former lovers, drug cartels and a murderous porn star.

In 1995, 16-year-old student Adrianne Jones is found shot to death in Grand Prairie, Texas. The police have no strong suspects, until nine months later when a game of truth-or-dare leads to a startling confession.

Six-year-old beauty-queen JonBenet Ramsey is found murdered in her Boulder, Colorado, home in 1996. Investigators try to unravel if she was killed in a kidnapping gone wrong, by a home intruder or by one of her own family.

A lone survivor is the only witness who can help police track down a serial killer known as the Grim Sleeper, who preys on women in South-Central Los Angeles. After decades of searching, police hone in on an unlikely suspect.

The small town of Craig, Alaska, is shocked when the charred body of Lauri Waterman is discovered. Police have no leads until they question a former boyfriend of Lauri's daughter, who claims he knows who killed Lauri.

An army surgeon, Jeffrey MacDonald, is the lone survivor of a brutal 1970 home invasion that claims the lives of his family. However, authorities doubt his story of murderous hippies.