Mystery Diagnosis

Jessica is a healthy teenager living with her parents in suburban New York. At the start of her freshman year in high school, she has bizarre episodes where she sleeps for 10 days straight. Edward Leigh knows the importance of looking good, and feeling good. But his healthy routine is thrown into chaos when he starts to experience abdominal pains at age 38.

A doctor administers surgery to identify and remove a young women's tumor, but finds something no one had noticed before. An avid marathon runner experiences escalating and unexplainable fatigue. His doctor tries to find out why.

Meredith Estes has baffling symptoms that can't be explained until she undergoes a risky left temporal craniotomy. Doug Posluszny can't explain his physical deterioration until an old acquaintance leads him to a physician who may have an answer.

Jennifer Fagenson takes aspirin to help alleviate altitude sickness, but ends up being rushed to the hospital. In 1998, Joyce Gonzales feels sharp, needle-like pain shooting up her left arm. Within weeks the pain mysteriously spreads.

JoAnn Citrone and her husband decide to start a family after enduring three long years of negative pregnancy tests. A man appears to suffer an embolism, but the source of these life-threatening blood clots and how he has survived them stumps doctors.

Infant Collin Campbell experiences sinus infections, chest congestion, and labored breathing. Laura McCann begins having stomach problems and diarrhea. Quettia Davis steps on a crochet hook and strange things begin to happen to her body.

Ashley's illness began with chronic diarrhea as an infant, and branched out to such diverse symptoms as ADHD and cataracts. Nissa, an ER nurse, took sick with the flu and was diagnosed with Lymphoma before swelling in her hands gave her illness away.

Brenda and Jake are thrilled with the birth of their first child, but over the next couple of days, Isabel stops eating, becomes more lethargic and turns an alarming grey color. Five-year-old twins Noah and Alexis Beery have battled a bizarre array of seemingly unrelated symptoms their whole lives.