Veterinarians Dr. Blue, Dr. Ross and Dr. Lavigne move to Houston to open a veterinary hospital. The practice stays busy with a range of cases but must adapt when one of the doctors has a car accident and faces a long recovery.

Dr. Ross returns to the clinic, but a check-up with a large pet proves to be too much, too soon. When pregnant Frenchie goes into early labor, Dr. Lavigne performs an emergency C-section. Dr. Blue tries to lift Dr. Ross's spirits.

While Dr. Blue and Dr. Ross help a client at their goat farm, Dr. Lavigne must save a pup with an obstruction in his intestines and a concerned family waiting.

Dr. Ross buys a mobile unit for community outreach. Back at the clinic, Dr. Ross examines an iguana for an abscess, and Dr. Lavigne helps a paraplegic dachshund get a new set of wheels.

As Houston floods, the clinic takes in and treats displaced animals. The veterinarians examine a tiger found wandering in a neighborhood and treat a puppy that contracted a deadly disease from standing water.

Dr. Ross performs a life-altering surgery on a sweet pup given a second chance at life, while Dr. Lavigne examines a prickly pet. After treating an injured owl, Dr. Blue joins Dr. Ross on a pig farm to examine a sick litter.

Dr. Lavigne removes tumors from an older dog, while Dr. Ross tries to save a rabbit’s foot that’s been damaged by a dog attack. Before he can compete with Dr. Ross in a puppy-training competition, Dr. Blue visits a farm to castrate an aggressive donkey.

The clock is ticking as Dr. Blue performs an emergency C-section on a mother with two puppies stuck in her uterus, while Dr. Ross and Dr. Lavigne work on pets with serious eye issues. The vets test their on-camera skills to create a video for the clinic.