After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.

Following Mr. Nobody's capture of The Chief, the Doom Patrol investigate the mysterious albino donkey and discover it's a door to another universe, where Mr. Nobody is in control.

The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between The Chief and the two villains.

Niles' old friend unexpectedly enlists the Doom Patrol into helping him avert the end of the world.

With the apocalypse in full swing, the Doom Patrol must work with an unlikely ally, and a very special pug, to stop the end of the world.

Jane, Larry and Rita visit a school where Niles' previous team of heroes has retired.

After a violent outburst from Cliff, the team engages in some self-led group therapy.

A sentient, gender-queer, teleporting street named Danny is hunted by a secret government agency.

Jane retreats to the Underground, a treacherous place deep within her own mindspace.

Vic and Rita face a dangerous man called The Beard Hunter, who's been activated by the Bureau of Normalcy to find Niles Caulder.

While Larry pays a visit to his lost love, John, Cliff travels with Rita down to Gator Country.

With Vic captured and held at the Ant Farm, his father hatches a plan with the rest of the Doom Patrol to break him out. Naturally, things go awry.

The Doom Patrol tries to restore the memories and abilities of Flex Mentallo, while Rita confronts her self-doubt and Larry realizes how tied he is to the Negative Spirit.

The Doom Patrol lands on the threshold of rescuing the Chief from the clutches of Mr. Nobody.

The team tries to cope with a hard truth as Mr. Nobody prepares for his final act of vengeance.