Pan Am’s state of the art jetliner embarks on its maiden voyage from New York to London, and into a rapidly changing world of romance and international intrigue.

Flying to Paris, Dean hopes to find Bridget, Kate and Laura’s mother shows up unexpectedly with a surprise, and Maggie fends off a passenger’s unwanted advances.

On a trip to Berlin, Maggie will stop at nothing to meet President Kennedy. Kate tries to help a spy defect from East Germany, and Colette confronts childhood trauma.

Kate navigates a frustrating mission for the CIA on trip to Burma and Indonesia, while an American space mission reminds Ted of his dreams of being an astronaut.

Kate’s latest spy mission: seducing a handsome Yugoslavian at The Monte Carlo Grand Prix. Dean begins a risky affair and Laura tries to return a ring to her ex-fiancé.

Maggie tries to save her job by adding to the lies she’s already told to get hired, Dean’s affair gets serious, and Kate is drawn deeper into international espionage.

As Kate's (Kelli Garner) personal feelings for Niko Lonza place the life of the Yugoslavian diplomat in danger, Laura's (Margot Robbie) efforts to help an African American sailor on a layover in New York spark a racist attack.

A violent hurricane and an elderly passenger’s heart attack force Dean to make an emergency landing in war-torn Haiti, and Colette takes a young refugee under her wing.

As Maggie risks her job to help fly an activist to a rally in London, Kate is sent on a dangerous mission by the CIA, and Dean takes Colette to visit his parents.

Kate tries to hide her role in the death of a Russian spy, Bridget hopes to resume her relationship with Dean, and Maggie’s affair with a congressman heats up.

Kate is sent to find a missing double agent in Moscow, and Dean copes with Bridget’s return. Meanwhile, Maggie struggles to balance her politics with her passion.

Colette is attracted to a passenger, but a jealous Dean suspects he is a smuggler. Kate tries to pickpocket a spy, and Ted learns that his fiancée is attracted to women.

Laura and Kate each face relationship challenges, Dean struggles to end an affair, and Colette chaperones a precocious twelve-year-old passenger.

A prince’s courtship exposes a surprise in Colette’s past, while Ted is unsure about marrying Amanda. Kate suspects a double agent, and Maggie dabbles in smuggling.