The Waldrops are a sweet family from Alabama with three lively boys. Parents Courtney and Eric get the shock of their lives when Courtney becomes pregnant with sextuplets, and they face becoming the parents of nine kids overnight.

Courtney and Eric struggle through a high-risk delivery. Six premature babies must survive the NICU and prepare to come home during a national flu crisis. One baby takes a turn for the worse as the family faces mounting expenses.

Courtney struggles to split her time between the babies and the older boys, while Eric takes on more work to keep up with expenses. The family attempts their first public outing with the sextuplets on Mother's Day.

Courtney and Eric bring the sextuplets to the twins' baseball game, but the babies become a big distraction. Eric faces a major financial decision, while two babies need to see the cardiologist, and one faces possible surgery.

It's a week of milestones and meltdowns. The family's first drive in their big van is scary. The twins graduate from kindergarten, but Bridge has a major fit. The sextuplets turn 6-months, and a group photo shoot turns chaotic.

Courtney and Eric stress about hosting a 5K charity event while also making sure the six babies stay on track developmentally. Major decisions need to be made since maternity leave pay is ending and they may be losing their nanny.