Thousands of hungry pythons are invading the Everglades and destroying wildlife. Snake hunter Dusty Crum races to remove as many of these predators as possible before breeding season makes the problem worse.

When their territory is overrun by rival hunters, Dusty Crum and his team head deep into the swamp and risk a night raid in the dangerous Sawgrass Plains. Their gamble pays off when they catch a 16-foot female python.

Snake hunter Dusty Crum and his team set up an outpost deep in the swamp where there's less competition from other hunters but more danger from alligators and panthers.

With the snake breeding season nearly over, Dusty Crum and his team explore an abandoned missile factory that could hold the biggest concentration of pythons in the Everglades.

Deep inside a dense forest near Miami, the team is catching pythons before they can lay eggs. After cooking up some snake meat for lunch, they talk with a geneticist who says they have caught a new hybrid species of python.

High temperatures send snakes into hiding, so hunter Dusty Crum and his team go on a night raid. When a potentially record-breaking python slips out of Dusty's hands, he becomes obsessed with tracking down the dangerous reptile.