In 2014, four women vanish from Chillicothe, Ohio. When two are later found dead, fears of a serial killer mount when a fifth woman goes missing in 2015. Before police can fully investigate the fifth missing woman, another body is found.

While searching for the fifth missing woman, another body is found. With the help of an anonymous tip, police are onto a possible suspect within hours. The community digs in once again on the possibility of a serial killer.

When two bodies are found in the same area one year apart, people wonder if it could be a serial killer's dumping ground. Connections between two victims become clearer as one investigation is revisited.

After discovering one of the missing women was friends with one of the women found dead, police redouble their efforts to find the missing woman. A person of interest is considered when the news of another missing girl sends Chillicothe into a panic.

The search for a pregnant 20 year old ends, while a search for another missing woman kicks into high gear. The town of Chillicothe, Ohio, seeks answers to all six cases.

In the final installment of The Vanishing Women, police chase down a terrifying new lead in a nearby town. Meanwhile, Jason McCrary, accused of murdering Timberly Claytor, goes to trial.