In the aftermath of the Gaza Strip attack that seriously wounded Donna and killed Admiral Fitzwallace and two American congressmen, Bartlet faces strong opposition to his peace plans. Meanwhile, Josh hovers worriedly by Donna's bed in a German military hospital. As doctors try to stabilize Donna's deteriorating condition, no one knows whether or not she will suffer brain damage if she survives.

Bartlet arranges for representatives from Israel and Palestine to visit Camp David in Maryland for peace negotiations. Leo remains at the White House in order to give the official order to attack the Ein Hawa terrorist training camp in Syria.

Before signing the Middle East peace accord, Bartlet orders his staff to enlist the support of the United States House of Representatives and the United Nations. Josh and Toby are assigned the task of getting congressional backing. Meanwhile, C.J. works to confirm international alliance with the United Nations Security Council. Donna returns to work, and Charlie refuses to take an exam.

An emissary from the Republic of Georgia visits the White House and offers weapons-grade uranium stored in a research reactor the Russians left behind when they pulled out of Georgia. Meanwhile, Josh looks for tax cut support from the Democratic Congressional Campaign Committee and along the way meets with Matthew Santos, a bright and enigmatic congressman from Texas.

Josh test-drives an oversized SUV and crashes into a hybrid car, resulting in bad publicity for the White House. Annabeth Schott, the new press secretary, has been on the job for only a week and is preparing to encounter the press corps for the first time. Toby worries that she looks too young and may not be ready for the corps' probing questions.

The United States peacekeeping compound is attacked, and American soldiers are killed. As the White House struggles to control the story, the father of a slain soldier speaks out against the mission. Democratic Congressman Matthew Santos attaches the Patients' Bill of Rights he wrote to a Republican piece of legislation that keeps the Democratic elements while maintaining a Republican agenda.

Final preparations are being made for Bartlet's visit to China when he accepts a flag from the delegation representing the Taiwanese Independence Movement--prompting China to prepare for military action. Recurring guest star ED O'NEILL ("Married...with Children") appears as Governor Eric Baker.

At a Bartlet family birthday, magicians PENN & TELLER (themselves) burn the American flag in the White House, prompting a publicity nightmare. Aboard Air Force One, Bartlet is stricken by a paralyzing episode of his multiple sclerosis. And Josh is approached to handle the Vice President's presidential campaign.

As Bartlet and his staff arrive in China for a critical meeting, the President is still suffering the paralyzing effects of multiple sclerosis. Meanwhile, an asteroid is headed for the U.S., leaving Josh and Leo to deal with the potential consequences.

The press circulates an untrue rumor about C.J. A controversial amendment banning gay marriage is added to the budget. Josh convinces Santos to vie for the office of President. Bartlet tries to handle his latest recurrence of multiple sclerosis. And Donna works for Vice President Robert Russell in his New Hampshire presidential campaign headquarters.

Josh travels to New Hampshire with Santos to establish their campaign headquarters. But problems arise from the beginning when they set up the office in an abandoned shack, and personal differences about the campaign's goals become evident. Meanwhile, Donna and Will work together on the Vice President's campaign.

The day after the President's annual State of the Union address, the harried staff deals with one emergency situation after another. Kate works on a sensitive situation in Bolivia while C.J. handles one in North Korea, and Toby concentrates on unemployment. To find inspiration, Leo starts the first day in a new capacity by watching State of the Union speeches from previous years.

The Midwestern state of Iowa is the location for the first presidential debate among the candidates. At the Iowa Corn Growers' Expo, Vice President Russell gives the first speech. Matthew Santos and Arnold Vinick follow, and the differences between the candidates become very clear. Josh struggles to understand how he can guide Santos in the race.

On Valentine's Day, an Iranian fighter jet accidentally shoots down a British passenger plane--killing 100 people--but C.J. is reluctant to awaken the President even as the hawkish British prime minister considers bombing Iran's nuclear reactors in retaliation. Meanwhile, Abbey and C.J. feud over the President's schedule for total rest.

Five days before the New Hampshire primary, a desperate Josh must get his trailing candidate, Congressman Matthew Santos, into the local debate between the two front-runners, Vice President Russell and John Hoynes. Josh doesn't succeed, and his candidate's campaign is doomed--until they gamble on staging their own debate.

Vice President Russell appears to be the frontrunner for the Democratic nomination for President. But a new contender, Senator Rafferty, gives an amazing speech. Josh continues to firmly support Santos and discovers an interesting link between Senator Rafferty's health care plan and one President Bartlet created--that only a White House insider would know.

Congressman Santos masterminds a plot to pass the President's stem cell bill while the Republicans aren't paying attention. Members of a group of middle school children who are part of the Future Leaders for Democracy visit the White House and seek out Toby to discuss the voting age. And Kate deals with an impending invasion of Canada.

Santos travels to Sacramento, California, for the last few days before Super Tuesday. While he's trying to gather support for his healthcare agenda, Santos is pressured by the media to reveal his stand on California legislation that would provide driver's licenses to illegal immigrants. Russell decides not to go to California, and Hoynes capably dodges the issue.

Speculations surround the nexus between communist Cuba and the democratic United States. Bartlet is propelled into a dubious conundrum--continue secret talks with Cuba's ailing dictator and lift an antiquated embargo or yield to bipartisan political fallout and reaffirm 40-year-old sanctions. Meanwhile, Leo and Kate discover they have more in common than politics.

After winning the Republican nomination for presidency, Arnold Vinick begins working on his campaign. Bruno Gianelli, a political strategist, gives the Republican candidate advice about choosing a vice president and handling Vinick's latest controversy--his failure to attend church. Meanwhile, the Democrats are stuck in a three-way race for enough delegates to win the Democratic nomination.

The success of the impeccably organized Republican Convention contrasts with the Democrats who look in disarray as the candidates continue to battle to become the Democratic Party presidential nominee. Bartlet asks Leo to take control and organize the upcoming convention. Meanwhile, the International Space Station is losing oxygen, jeopardizing the lives of the three astronauts aboard.

At the Democratic Party National Convention, the race to become the presidential nominee has narrowed to three candidates: Russell, Hoynes and Santos. Also, Bartlet wrestles with the decision to risk national security and launch the secret defense shuttle to rescue the astronauts trapped at the Space Station--or let them die.