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In the Season Four finale, after a massive bus accident left House without recollection of four hours prior to the accident, he and the team put the pieces of his memory together and discovered Wilson's girlfriend Amber was on the bus with him and was fatally injured. Wilson had to face the shocking realization that House was directly involved in Amber's death. As Season Five opens, with his ...
In the aftermath of Amber's death, Wilson announces his resignation on the season premiere.
The team investigates a string of mysterious deaths centering around a single organ donor, and House hires a private investigator to snoop on Wilson and the team.
A struggling artist falls ill and the team must use a discerning eye to uncover what may be hiding below the surface.
House gets back to his roots and a patient falls ill searching for her own.
Thirteen's personal life is brought to the examining room table.
The team treats a sleepwalking patient experiencing unexplained blackouts and Cuddy decides to adopt a newborn baby.
House and the team treat an agoraphobic patient who refuses to leave his home.
A parentless teenager falls mysteriously ill and Foreman takes on a case of his own free from House's supervision.
House and Thirteen are taken hostage by a man willing to kill for a diagnosis.
House and the team treat a fitness fanatic with a slimming secret.
House and the team ring in the holidays with a new medical mystery. Lori Petty Guest Stars.
House treats a patient whose chronic pain pushes him to the edge.
House tests Cameron's patience as the team takes on the case of a too-good-to-be-true teacher.
The team treats a former doctor who gave up her career in the pursuit of happiness.
A fake case becomes a real one as the team treats a priest whose past has taken his faith from him.
The case of a teenage patient with male and female DNA sends the team in different directions.
House and the team treat a patient who uncontrollably speaks his mind. Jay Karnes ("The Shield") Guest-Stars.
A woman who believes her cat has predicted her death desperately seeks House's help. Judy Greer ("27 Dresses") Guest-Stars.
A man injured in a bicycle accident is "locked in" his own body and needs the help of House and the team to save his life. Mos Def ("Be Kind Rewind") Guest-Stars.
House and the team work to keep a husband and wife alive but are forced to make a difficult decision as both patients' conditions deteriorate. Meat Loaf Guest-Stars.
Cameron takes the lead when an environmental activist falls mysteriously ill.
House and the team treat a deaf teenager.
As House and the team try to diagnose a dying ballerina, House attempts to diagnose himself.
House takes on a case of mind over matter as a patient's right and left brain struggle for dominance. Carl Reiner ("Ocean's Thirteen") Guest-Stars.