Tick and Arthur have freed the City from The Terror - now they must defend it from new villains and old enemies. That is if they can convince AEGIS, the government agency in charge of superhero regulation, that they deserve the job. But now that the City is ‘safe enough to protect’ Tick and Arthur begin to see they’ve got competition...
Tick and Arthur go on their first patrol of The City, battle a bank robbing monstrosity, and attract the attention of AEGIS. Dot has a weird day. She and Overkill have a few drinks and compare plights.
The local AEGIS branch has reopened - Tick and Arthur tour the facility and take the hero test. Overkill and Dangerboat prepare to go back on the lam, but Dot intervenes. Superian encounters social media, and Miss Lint decides on a new villain strategy.
Tick and Arthur pursue the trail of the bank robbers into the gambling underworld. Overkill reconnects with an old mentor and learns his enemy The Duke may still be alive.
A strange bit of information sends Dangerboat in to lockdown. Dot frees Overkill of a burden and joins him on a mission. Meanwhile, Superian takes Arthur's advice - badly.
Tick and Arthur hunt their bank robbing nemesis in the sewers, aided by new superpowered pals - but Arthur must face this enemy alone. Dot and Overkill question a piece of furniture and learn one of The Duke's secrets.
Tick and Arthur fight a beaurocratic battle to save an innocent creature from AEGIS experimentation. Dot tours an AEGIS open house, as Overkill visits an old friend.
Tick and Arthur, with the help of Tinfoil Kevin, confront the Donnelley brothers and rescue their precious hostages. Walter starts acting oddly. Dot and Overkill storm the Duke's lair.
Tick and Arthur must take care of six adorable babies while hiding them from AEGIS. Joan and Kevin lend a hand. Superian unexpectedly drops in for a therapy session.
Tick and Arthur join the Flag-5 and undergo initiation with their fellow team members. Walter and Dot throw a wrench into Arthur's dream come true. The Duke makes a deadly move on AEGIS.
The Tick, Arthur, Dot, and the rest of the family must battle The Duke and AEGIS itself. Miss Lint reveals her true goal and Superian weighs the pros and cons of accidental genocide.
Tick and Arthur return to defend the City from new villains and old enemies. But they discover looks can be deceiving and everyone’s got a secret to hide.