Angus "Mac" MacGyver (Lucas Till) and Jack Dalton (George Eads), special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to destroy hundreds of thousands of people with one single drop. Sandrine Holt, Justin Hires and Tristin Mays also star.

MacGyver and the team attempt to rescue Sarah (Amy Acker), Jack’s former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.

MacGyver and the team are in Malaysia to extract a terrorist groups' money man, Ralph (Oliver Cooper), who holds key intel to an impending attack.

Mac and Jack partner with older versions of themselves, a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow.

Using only an armrest, a curtain rod and a toothpick, MacGyver must fix a sabotaged train in order to protect a whistleblower who has proof that her boss is selling weapons to U.S. enemies.

Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, "The Ghost" (Niko Nicotera), a notorious criminal whose work killed his mentor, and track him down before he strikes again.

MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, using only batteries and salt, and track him to his cartel's secret location and dismantle it.

When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. David Dastmalchian guest stars.

With only a chisel and matchbook, MacGyver and team must defend themselves and the U.S. embassy workers in Latvia from extremists who are attempting to retrieve their leader. Also, Bozer faces a big decision now that he knows who Mac really is.

Mac and the team have no time to reminisce while visiting Mac's and Bozer's hometown when they immediately start searching for a kidnapped prodigy from Mac's old middle school, Valerie (Amiah Miller). John Heard guest stars.

MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III. Michael Michele guest stars.

Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organization that is trying to take down The Phoenix Foundation.

On the way back from capturing a war criminal, Mac and Jack's helicopter crashes in a remote area of Kazakhstan, injuring their pilot and allowing their prisoner to escape with Jack's gun.

Using a fish scaler and some fishing wire, Mac and Jack must track down a corrupt FBI agent who has framed a man for murder.

When Matty's goddaughter and her boyfriend are killed in a San Francisco park, Mac and the team investigate the crime and start to suspect that the 1970s Zodiac Killer has returned.

While tracking down the dangerous fugitive Aaron Deckard (Anthony DiRocco), Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark. Lance Gross, Sheryl Lee Ralph, Javicia Leslie and Jermaine Rivers guest star.

Bozer's first overseas mission goes terribly wrong when Mac and the team are blamed for a terrorist bombing and the Phoenix Foundation is forced to disavow them.

When Mac and the team travel to Hawaii to aid in earthquake relief efforts, they team up with Chin (Daniel Dae Kim) and Kono (Grace Park) from the Five-0 task force to rescue a group of government scientists trapped in a building.

Mac and Jack help Mac’s close friend from M.I.T. (Aly Michalka) after she fakes her own death to prevent someone from killing her in order to suppress her scientific research.

When the team intercepts a terror group's message meant for Murdoc, Mac poses as the psychopath to save the intended target and find out why they want Murdoc to assassinate him.

Murdoc moves forward with his plans for revenge against MacGyver by recruiting his recently released former cellmate to infiltrate the Phoenix Complex as a "lab technician" and kill every agent inside, on the first season finale.