After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.

Following Mr. Nobody's capture of The Chief, the Doom Patrol investigate the mysterious albino donkey and discover it's a door to another universe, where Mr. Nobody is in control.

The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between The Chief and the two villains.

Willoughby Kipling (MARK SHEPPARD) conscripts the Doom Patrol into helping him avert the end of the world by stopping a nihilistic cult.

With the Apocalypse in full swing, the Doom Patrol must work with an unlikely ally - and a very special pug - to stop the end of the world.

Jane, Larry and Rita visit a school where the original Doom Patrol has retired. Meanwhile, Cliff & Vic bond over their mutual "father issues."

After a violent outburst from Cliff, the team engages in some self-led group therapy - leading to some growth within the group as they are knit closer together.

A sentient, gender-queer, teleporting street named Danny who's being hunted by the secret Bureau of Normalcy needs help from Niles - but gets Vic and Larry instead.

Jane retreats into The Underground, a treacherous place deep within her own mindspace, where she encounters her many personas and dark traumas of her past.

Vic and Rita face a dangerous man called The Beard Hunter, who's been activated by the Bureau of Normalcy to find Niles Caulder.

While Larry pays a visit to his long-lost love, Cliff and Rita travel to Gator Country to reconnect with his daughter. And Vic worries about his operating system.

With Vic captured and held at the Ant Farm, his father hatches a plan with the rest of the Doom Patrol to break him out. Naturally, things go awry.

The Doom Patrol tries to restore the memories and abilities of Flex Mentallo, while Rita confronts her self-doubt and Larry realizes how tied he is to the Negative Spirit.

With the help of Flex and Danny the Street, the Doom Patrol enter the White Space to rescue the Chief from Mr. Nobody. But Nobody offers them a deal that's hard to resist.

The team tries to cope with a hard truth as Mr. Nobody prepares for his final act of vengeance.