In Japan's Warring States period, Lord Daigo Kagemitsu makes a pact with 12 demons, exchanging his unborn son for the prosperity of his lands. The child is born malformed and is set adrift in a river, while Kagemitsu's lands thrive as promised. Years later, young thief Dororo encounters the mysterious "Hyakkimaru", a boy whose arms are blades and whose visionless eyes seem able to see monsters.
In Japan's Warring States period, Lord Daigo Kagemitsu makes a pact with 12 demons, offering them his unborn son in exchange for the prosperity of his lands. Years later, young thief Dororo is attacked by a ghoul but rescued by a mysterious boy, whose body parts turn out to be almost entirely prosthetic.
Dororo and Hyakkimaru happen upon a village and are brought before its chief, Lady Bandai. However, Hyakkimaru inexplicably draws his sword in her presence, resulting in both him and Dororo being locked in a storehouse by the villagers. It turns out they are not the only ones confined there...
Jukai is a doctor who travels the land fitting prosthetic arms and legs to those who have lost their limbs in war. One day, on the riverbank he finds a baby missing most of its body parts. He decides to raise the child, who he names “Hyakkimaru”. Jukai provides the child with prostheses, but the time comes when Hyakkimaru sets out on a journey to recover his own body parts.