Dr. Mercy tries to remove Price's lipoma, which is so big that it has gotten in the way of his relationship. Ashley's case of neurofibromatosis is one of the worst in the country. Becca was born with a birthmark that covers the majority of her face.

Joseph's neck lipoma gets in the way of everything he does. Rachel's condition gives her a full beard that she shaves daily. Summer has seven cysts, including one she calls her "unicorn horn."

Tiffany has a rare condition that has left her in so much pain, she's couch bound. Brad's face is covered in nodules from a condition that affects less than one in a million people. Lydia's life is majorly impacted by her excessive sweating.

Jorge's case of rhinophyma is so bad that he has a difficult time breathing. Tracy's body is covered in hundreds of lipomas. Cha comes to Dr. Mercy to help her gain her confidence back due to the bumps on her face.

Ramon's keloids on the back of his head are so large that he may require a skin graft if removed. Lauren has a condition that gives her bumps inside and outside of her body. Tiana has an unknown condition, giving her what looks like four breasts.

Tiana hopes Dr. Mercy can figure out how to get rid of her two extra breasts. Michael wants his giant patches of skin tags removed for his 40th birthday. Chandra's lipoma is weighing her down physically and emotionally.