"Dottie the body" lost her confidence when a large bump started growing between her thighs. Dr. Lee brings in a new, young doctor to help Tim with his big, bumpy nose. Karime is insecure about her birthmark that looks like a black eye.

Katrina has oozing, smelly boils that have taken over her life. Kim's head-to-toe tumors interfere with her sleep apnea mask, resulting in constant exhaustion.

Tierra is a musician with massive bumps on her ears that hold her back from performing. Dr. Zoe assists Dr. Lee helping Ryan, whose numerous head bumps undermine his life journey.

Dr. Lyndsey assists Dr. Lee with Lance's notoriously big bump that halted his rap dreams. Shelby has lost control of her sweet tooth, her health, and the mystery bumps she has developed.

Anthony is trying to move on from his troubled past, but his huge thigh lump is holding him back. Mary has a mysterious 70-year-old bump that amazes Drs. Lee and Tomassian.

Dr. Lyndsey joins Dr. Lee to help David, who is fearful that the lump on his jaw might be cancer. Carla has a large, mysterious bulge on her thigh that concerns Dr. Lee. James has over 70 skin tags that he wants removed so he can get his beach body back.

Bill's swinging arm growth prevents him from living his retirement dreams. Regina distracts from the many moles on her face with a vibrant style. Budding med student Gili helps Dr. Lee solve the mystery of Cowboy Carter's extensive rash.

Dr. Lee asks Dr. Zoe to help double-team needle-shy Mary Ann's crusty skin. Isaiah's mom is concerned he is ignoring the large, growing lump over his lower spine. Maressa worries about the dangers of treating the oozing skin covering her ankles and body.

Jason has become a recluse because of a giant growth on the back of his neck.