Three 40-something best friends from Los Angeles are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that all the norms from Los Angeles don't apply anymore, they decide to celebrate a city that values real women and stay where they're still considered hot.
A baby unexpectedly enters the ladies' lives. Meanwhile, an unhinged super-vixen offers Melanie a great job and Elka gets the 'upper hand' with her boyfriend, Pierre.
Melanie's boss puts her in an awkward position with her attractive co-worker, while Joy is self-conscious about fitting in at college. Meanwhile, Victoria's director asks her to change her appearance, and Elka keeps a secret.
Victoria schemes to get to the bottom of her co-star's true intentions. Joy is still trying to fit in at college while Elka befriends the popular girls. Meanwhile, Melanie gets herself into a dishonest situation.
Melanie drives herself crazy wondering if Alec heard her confess her feelings for him. Elka and Mamie scam Joy into helping them with their new business. Victoria and her costar fake being lovers as a publicity stunt.
During a trip to the vet, Elka tries to teach Mamie how to flirt. Joy's turned on by the idea of male pet-owners - especially when a smoldering fireman walks in. Victoria's interviewed by her daughter about second acts in life.
Melanie's embroiled in an office love triangle. Joy learns a tidbit about Sean that threatens her fireman fantasy. Victoria's insecurity about dating a movie star leads her to extremes. Elka and Mamie have a run-in with the law.
Joy's mom meets her new family members at Wilbur's christening. To avoid friction with her mom, Joy makes her son Owen pretend to be someone else. Elka touches up a church fresco. Victoria's incessant Emmet talk annoys Melanie.
Melanie wants her first time with Alec to be perfect but ends up "fake-porning" it. Joy works as an extra on Victoria and Emmet's movie and meets a forbidden love interest. Elka and Mamie are bad influences on baby Wilbur.
Victoria has doubts about her relationship with Emmet when Nikki, a woman from his past, shows up. Meanwhile, Melanie and Elka deal with an unwanted house guest. Joy falls for a handsome doctor but he has just one flaw...
Melanie sets Joy up with her boyfriend's friend, Bill. Elka takes over as Victoria's agent. Secrets and gossip circulate and come to a head at the ladies' monthly game night.
At a rustic spa retreat, Joy tests her newfound sleuthing skills on a suspicious Yogi. Victoria learns what it means to be a responsible friend. Mamie confronts Elka about her bossiness. Melanie's fasting causes hallucinations.
Victoria's movie is ending and she's unsure where that leaves her relationship with Emmet. Melanie wonders where her relationship with Alec is going. Joy uncovers something mysterious about Elka during her new internship.
When Elka and Mamie's illegal business activities put them all in danger, Joy, Melanie, and Victoria step in to save the day and wind up getting help from a local mobster (William Shatner) and his mother (Shirley Jones).
Victoria's sister (Jean Smart) tricks her into coming home for a visit. She and the ladies find her mother Penny (Carol Burnett) in an alarming state. Joy and Melanie re-visit the '70s. Elka (Betty White) gives Penny advice.
Between Victoria's five marriages and Emmet's four, Emmet (Alan Dale) enlists the ladies' help in finding a surprising way to propose, but Victoria is not the only one in for a surprise.
Victoria acts as a spokesmodel and inadvertently commits to a very generous donation on national TV. Joy works with private investigator, Bob (Dave Foley), and reunites with hot Brony fireman, Sean (Eddie Cibrian).
The ladies try to make Wilbur's first birthday memorable and Melanie and Alec (Jay Harrington) contemplate what it would be like to have a family together.
Melanie rebounds with the unsavory Danny (Tom Arnold) but is soon juggling two men, including a blast from the past: Dr. Everett (Jack Wagner). Victoria hires a shady lawyer to help Emmet. Joy and Elka compete in film class.
While preparing for a "Hot in Cleveland" show taping, the ladies are surprised by a special guest and begin to reminisce about their favorite moments and bloopers from Season 4.
Lying to Cleveland's top pediatrician leads Joy to host a traditional Indian dinner party. When Victoria's wedding planner (Michael Urie) arrives, the stage is set for a classic farce--appropriate as Elka auditions for a play.
Melanie gets her dream engagement ring, but not the way she expected, Joy deals with mysterious family issues, and Victoria tests a new product from the Mrs. Ladypants line. Elka and Mamie test jokes for a Senior Center roast.
Stuck in the hospital on the day of her bachelorette trip, Victoria contacts her many ex-husbands to find out where things went wrong. Joy and Melanie fantasize over a man in a coma and Elka and Mamie bring Vegas to Cleveland.
Elka (Betty White) & Mamie (Georgia Engel) reunite their bowling team: Diane (Mary Tyler Moore), Peg (Cloris Leachman), & Angie (Valerie Harper). Joy, Victoria & Melanie date a professor (George Hamilton), director & surgeon.
It's the big day of Victoria's wedding to incarcerated movie star Emmet Lawson (Alan Dale). Elka (Betty White) helps Joy reunite with her baby daddy (Craig Ferguson), who she hasn't seen in thirty two years.