Leonardo

Milan, 1506. Leonardo is arrested for poisoning Caterina de Cremona. After protesting his innocence to Stefano Giraldi, Leonardo remembers back to his days as an apprentice in Andrea del Verrocchio's studio, where he first meets Caterina.

With Leonardo's successes recognized and his reputation growing, a risky decision sets to destroy everything he has worked for.

Leonardo ventures to Milan with a determination to claim an offer of patronage from the Duke Regent, Ludovico Sforza. A newfound relationship helps liberate Leonardo's imagination.

As Salaì, a resourceful thief, distracts Leonardo from Caterina, Leonardo ends up in a race against time with a costly decision to make.

Leonardo is given a new art commission but struggles with inner turmoil. Putting his creativity to the test and experimenting with a new technique, he must deal with the consequences of his actions and results.

Returning to Florence, an uninspired Leonardo accepts to paint the portrait of Lisa Gherardini, that will become the Mona Lisa. After failing to repair his relationship with Caterina, Leonardo goes to Imola.

Reunited with Caterina, Leonardo is frustrated by the growing success of young artist Michelangelo. Leonardo is persuaded to accept a new commission, a giant fresco of the Battle of Anghiari, but faces competition from his newfound rival.

Stefano races to save Leonardo from execution. With a newfound secret discovery but no evidence, an epiphany leads Stefano going to a remote source for help. Stefano realizes the answer he seeks lies in the man he is striving to save.