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Three years following the events of season two, Alex abandons a peaceful, anonymous life in Italy to help Ryan rescue Shelby from a notorious black market arms dealer who is holding her hostage and demanding a ransom only Alex can provide.

In tracking down the origin of a deadly strain of tuberculosis threatening Americans, Agent Ryan Booth must go undercover and infiltrate a white supremacist organization.

The team protects an ex-CIA agent in order to take down a cartel kingpin. Elsewhere, Ryan goes on a date with La Culebra's field general in order to track down a mole who is leaking information to the cartel.

Alex and McQuigg protect a young prince following an assassination attempt, and find the traitor in his midst.

Alex, McQuigg, Deep, and Owen hunt down Southeast Asian terrorists who have coerced an innocent physicist into stealing uranium and building a nuclear bomb.

Criminal mastermind Dante Warwick is holding Jocelyn's former business partner and lover Frank Marlow captive, and the team must come to his rescue.

The team is tasked with protecting a group of scientists that have created a bullet that can target an individual person's heartbeat.

The team works to bring down the head of a private military contracting company who is in bed with North Korea.

Shelby reunites with someone from her past.

When Owen and McQuigg learn heartbreaking news about family members, the team goes on high alert as they quickly learn nowhere is safe.

Conor Devlin has plans of his own when he plots revenge and returns to his home country, Ireland. Meanwhile, the team unknowingly finds themselves as a pawn in his plans.

Conor Devlin continues to seek revenge as someone from Alex's past comes back into her life.

The team finally comes face-to-face with Conor Devlin.