In Tulsa, detectives rely on DNA evidence to track down the killer of a homeless woman who was raped, strangled to death, and thrown into a dumpster. In Harris County, investigators debunk an argument based on a footprint located on the victim's back.

Three cases from the First 48 archive follow investigations where witnesses bravely shared case-breaking information.

Three cases from the First 48 archive follow investigations into the deaths of innocent people who happened to cross paths with a killer.

Three Tulsa cases featuring female suspects. A killer unknowingly leads detectives to a body. An innocent mother is murdered with a butcher knife. A homeless couple is taken in by a friend, but when he ends up dead, someone makes a fateful choice.

Three cases from The First 48 archive where friends turned into enemies. In Cleveland, a backyard hangout turns deadly. In Tulsa, a young man risks his life to save a friend's. In Gwinnett County, a family man is killed by those he trusted most.

First, a vengeful shooting spree in Tulsa leaves 2 slain. Then, a young mother in Dallas intervenes in a domestic dispute and pays with her life. Finally, a Tulsa man visits his ex-girlfriend and winds up dead.

In New Orleans, a double-shooting on Bourbon Street leaves only one survivor and the hope he can name the suspect. In Birmingham, when a young man and his girlfriend are shot in his home, only she survives.

First, in Tulsa, surveillance captures a group of people en route to a deadly shooting. Then, in Harris County,Texas, a turf war heats up as the camera looks on.