Three cases that feature families enveloped in personal tragedies. In New Orleans, two cousins have a deadly fight; in Memphis, a young couple disappear and their uncle's home holds a clue; and in Dallas, a woman brutally turns on her sister-in-law.

Three different approaches to suspect interviews are featured from The First 48. Detectives in Cleveland sit down with friends and the suspect in the murder of a young mother; the boyfriend of a missing woman is questioned in Harris County.

Three cases where things get out of control in a heated moment. In Birmingham, a man's body is found burned after an argument with a friend; in New Orleans, a man with cancer gets a ride home that ends in his murder.

A look back at three cases where forensics played a pivotal role in solving homicides. In Harris County, detectives rely on fingerprints to solve a father's carjacking and murder; in Charlotte, a slain woman's family finds justice through DNA.

When there are no witnesses, homicide detectives face an uphill climb to find the truth. Detectives in Cincinnati come across a bizarre homicide at an apartment fire; a Tulsa a woman found dead leaves police a clue that might solve her own murder.

Three cases driven by revenge and resentment. In Mobile, a man is executed in a parking lot; in Harris County, TX, pressing charges in an attempted robbery leads to a brutal murder; and in Tulsa, a gang member goes on the hunt after being called a name.

Three stories where a plan proved deadly for unwitting victims. In Dallas, a man is lured to his death in an abandoned apartment; a homeless man in Miami is brutally beaten with a rock; and a Tulsa woman's plan to help her sister goes horribly wrong.

Detectives in Atlanta find a woman's body in a trashcan; in Louisville, a domestic dispute turns into a homicide investigation; in Birmingham, doing a favor for a friend costs one man his life.

A look back at three First 48 cases where the victims were in the wrong place at the wrong time. In Tulsa, a case of road rage turns out to be something else entirely, In Harris County, investigators get to the bottom of a car wash shooting.

Haunting cases from The First 48 archive that stuck with investigators long after the arrest. In Memphis, a woman is dragged to her death. In Harris County, a young mother is found with her throat slashed.

Rookie detectives lead their first investigations in cases from The First 48 archive. In Louisville, a rookie leans on video surveillance. In Atlanta, a new detective utilizes facial recognition software to try and solve his case.

Three cases from The First 48 with puzzling motives. In Tulsa, a woman is brutally attacked as payback. In Dallas, a barber is gunned down by someone who greets him as a friend. In Atlanta, a man sticks up for a friend and becomes the target.

Three cases from The First 48 where veteran homicide detectives show how it's done. In Dallas, a woman is brutally killed in her home; in Memphis, a longtime investigator needs to convince a witness to give up the triggerman in a shooting; and more.

Examines three cases where homicides were committed in the name of love. In Dallas, a couple is shot to death on their doorstep; in Louisville, a hearing-impaired man is stabbed in his doorway; in Tulsa, a woman's body is found in a trash can.

Three cases that look at what happens when people become obsessed with revenge. In Harris County, a teenage girl is lured to her death; in Louisville, a man unleashes a cascade of bullets on a house full of sleeping people; and more.

Critical Minutes looks at three cases that take place in the brutal underworld of illegal drugs. In Tulsa, a homeless dealer is ambushed. In Cincinnati, an elderly man is strangled in his apartment. And a drug deal in Atlanta turns into a shootout.

Three cases that examine how and why some women kill. In Tulsa, a woman is shot and detectives are shocked by their suspect. In Birmingham, a mother is shot in front of her children. And in Charlotte, a couple is suspected of stabbing a man in his car.

Three cases that explore how money can lead to deadly fallouts. In Harris County, a Navy veteran is killed after coming home to a burglary in progress. In Mobile, a mother vanishes on a trip to the casino. In Dallas, a man is murdered with a hammer.

Three cases from The First 48 in which homicide suspects go on the run. In New Orleans, it's all hands on deck to find the triggermen in a mass shooting on Bourbon Street. In Dallas, an escaped convict is suspected in a stabbing. And more.

In Charlotte, two men are brutally attacked with a hammer in their sleep. In Dallas, a detective works his first triple homicide. And in Tulsa, a man is stabbed and the lead detective plunges into the world of homelessness as he searches for the killer.