A young autistic surgeon (Freddie Highmore) who relocates from Wyoming to California to complete his medical training relies on his top-notch skills to disprove his colleagues' skepticism.

When prejudices about his autism force Shaun (Freddie Highmore) to sit on the sidelines at St. Bonaventure, his colleagues don't hesitate to claim credit for his ideas.

As Shaun (Freddie Highmore) and Claire (Antonia Thomas) improvise to preserve a liver for a transplant, Andrews (Hill Harper) is pressured to partner with Melendez (Nicholas Gonzalez) on a wealthy patient's routine surgery.

Melendez (Nicholas Gonzalez) takes a risk to save a mother and her unborn child, placing the hospital in legal jeopardy. As Shaun (Freddie Highmore) struggles to adjust to his new life, he and Claire (Antonia Thomas) team up to treat a teenage porn actress.

After bonding with a young patient, Shaun suspects that he's been misdiagnosed with a fatal form of brain cancer. An elderly patient's allergic reaction exposes a longstanding rift with his son.

Shaun and Claire devise an experimental procedure capable of saving a young groom's leg and life, but the patient's loved ones must learn to work together. Meanwhile, Jared struggles to connect with a patient whose scars may prove too deep to overcome.

Dr. Shaun Murphy has to confront prejudice from an unlikely source when he takes on the case of a patient with autism, and Dr. Jared Kalu has to learn to accept his limitations as a surgeon.

During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun's traumatic day, Dr. Aaron Glassman worries that he isn't doing enough to help Shaun.

Shaun and Melendez team up to devise a heart surgery to save a gravely ill African boy. A missing tissue sample leaves a young mother facing potentially unnecessary surgery.

Members of the hospital's surgical team are initially impressed with a charming young doctor, but his true character puts one of them in an awkward position at work. Meanwhile, Glassman feels Shaun needs a little more support with his personal life and suggests he meet with a therapist. However, Shaun is determined to show him that he can do it on his own.

Dr. Marcus Andrews enlists Dr. Neil Melendez on a very sensitive kidney transplant between a pair of twins whose lives intersect in more ways than one. Meanwhile, overwhelmed by Dr. Aaron Glassman's attempts to have him meet with a therapist and the demands at work, Dr. Shaun Murphy decides to take an impromptu trip with his friend Lea and leave everything behind.

The twins suffer complications from their surgery forcing the team at San Jose Boneventure Hospital to make a life-changing decision. Meanwhile, Dr. Shaun Murphy returns to the hospital after his trip with Lea and decides he needs a more permanent change and gives Dr. Aaron Glassman his two weeks' notice.

Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez's personal life could be affecting his work and, ultimately, his patients lives.

As Shaun and Jared debate how to treat a twelve-year-old transgender girl’s cancer, Claire and a competitive new resident must work together to save a single father from a drug-resistant super bug.

An operation to correct a teenager’s heart defect puts Shaun and Dr. Morgan at odds. A new resident’s experience as a police officer leads him to doubt an imprisoned killer’s motives for wanting to be an organ donor.

When the team treats a patient who has to decide between a dangerous surgery that could change his life or remain the same, he asks Dr. Shaun Murphy what he would if he had that same choice.

Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.

Distracted by some troubling news about Glassman (Richard Schiff), Shaun (Freddie Highmore) makes a mistake that could end his career.