Totally Spies!

Terence is back and he calls in Tim Scam, Helga Von Guggen, Boogie Gus, and Myrna Beesbottom to create the 'League Aiming to Menace and Overthrow Spies' (LAMOS). The girls meet triplet students Skyler, Tyler, and Wyler and go on dates with them, however, they discover strange happenings involving them, and feel more fatigued.

During cheerleading practice, Mandy breaks a nail, but is offered a spot as a reporter on the school television. The girls are called in to clean up Jerry's office and organize the gadgets inventory. They discover a gadget that is actually a time machine which sends them 2025 years into the future.

Boogie Gus invents a ray gun that makes people younger and dress like the 1980s. He uses the weapon to zap the spies and others in town. In the subplot, Jerry reunites with an old band member and thinks about getting back into the music business.

Jerry gives the girls a vacation and a new car, but during their wild ride, the girls end up at Ocean Paradise (a.k.a. The O.P.), a seaside community where everyone acts very friendly and on their best behavior. However, the ideal and perfect society harbors a secret of brainwashing teens who disobey.

After receiving her report card in which she has failed all her classes, Alex is sent to Dorsal Academy in England. But the new boarding school is rather bizarre with students acting more like dolphins in their conversation, their choice of food, and their swimming ability, not to mention their noses.

A mime named Jazz Hands uses his accordion to transform entertainers into silent mimes. During the pursuit, Sam and Alex are zapped to mimes. In the subplot, Alex has developed a habit of sharing Sam and Clover's deepest secrets, so Sam and Clover strive to find a way to shut her up.

Clover and Mandy compete for the title of Miss Beverly Hills. Clover seeks the best full-body makeover spa in the area, only to discover that Mandy has also booked the same treatment. Meanwhile, Diminutive Smalls, a tiny WOOHP prisoner, has escaped and tries to sabotage Clover's makeover bed with a special microchip, however, he plants it in Mandy's machine.

When Jerry receives a bag of his favorite chocolates, he thanks the girls, but becomes increasingly angry after eating one. The girls soon get involved in a series of accidents, and trace the cause to the chocolates which contain Terence's Evil DNA.

Jerry is invited to star in a spy film, leaving the girls in charge of WOOHP business. But a series of kidnappings of Hollywood's top producers brings a trail that points to Jerry. The girls discover that the director is actually WOOHP villain Marco Lumiere, but must convince Jerry, who stubbornly believes all the events are part of their film production.

Following a humiliation in the lunchroom, Arnold is left depressed. That night, as they watch someone breaking into an armored van, Arnold dressed as a superhero appears, and attempts to capture the man. The van seals, and drives off a cliff. Sam, Clover, and Alex save Arnold beforehand, and make him swear to keep their identities secret.

A former famous manicurist has plotted revenge on a salon for stealing his customers by using his former customers as minions. And things go from bad to worse for the spies when Clover ends up becoming one of his minions, leaving only Sam and Alex to stop the powerful army from destroying their favorite salon.

Jerry sends the spies off for a holiday on the WOOHPtanic, but when a villain hijacks the ship and causes it to sink, the girls find themselves waking up aboard the ship with events beginning to repeat themselves.

The spies are sent to investigate a wave of cases where men have fallen into sleep deep, causing heartbreak to their significant others. At the house of one of the guys, they discover a plant that is able to move on its own as well as spray sleeping gas.

Three of the richest people in the world have disappeared. The girls are sent to protect the fifth richest person (having to skip over the fourth richest due to his confidence in his security system), the materialistic and conceited heiress Milan Stilton who has a particularly nasty robotic dog, Fufu.

As Clover and Mandy compete for head cheerleader of their high school, the girls are called to investigate the mysterious disappearance of top cheerleaders nationwide. After checking Buffy's house, they find a scrap of paper with a partly torn logo. Mandy then disappears

The girls must track down the cause of people being flash frozen based on the sound of a short motif that was recorded at the scene. Their pursuit leads to an ice cream truck, and a factory where its owner has been disgruntled by the snack and dessert trends taking away his customers, so he plans to freeze everyone and everything with his ice cream.

The girls are called to find the reason why women in Paris have been running away crying over their looks. They find one of the women, who has an ugly expression and trace the beauty products to a designer named Miss Vanity who has been recruiting models. The former beauty queen creates products that give the wearer any emotion they chose.

As they are at the fair, the spies are given three bracelets from an awful woman. Unfortunately, the woman who gives away the bracelets is none other than Helga Von Guggen, wearing an awful disguise. Worse still, the spies never recognized her, and she managed to lure them into her trap. As soon as they put the bracelets on their wrists, the spies suddenly pass out.

Jerry goes into a fashion store, only to be captured by L.A.M.O.S., and trapped in their submarine. He hears about their evil plan, and tries to warn the girls.

The girls are called to spy on Kyle Katz, a jewel thief who has never been caught and who plans a large heist on a special night where Venus, Earth, and some other planets are aligned. Kyle is extremely attractive to the three girls and is also aware that they have been watching him.

Beverly High's soccer team coach has retired, leaving Alex rather depressed about it, until she meets Bonita Bikham, a young woman who becomes the new coach. However, Bikham uses a soccer ball that contains a mind-control chip which changes Alex and two other girls into aggressive and powerful soccer players.

The spies are sent to investigate the mysterious disappearances of some shop owners in a town. They go undercover as farm workers, and uncover a demented farmer's plot to turn humans into vegetable-like beings. It is up to the spies to save the day.

The spies are sent to the moon to rescue a popular band called the Alpha Centauris who have gone missing. It is revealed that the leader of the band called Ziggy is also the villain.

After capturing a villain called the Inventor, the girls return to find that their mothers have returned. Learning that their daughters have been spies, the mothers order their daughters to quit.

The girls send Jerry a letter for help, then head to Mandy's chalet at the Sugarflake resort, where they rescue their moms from a runaway gondola lift. Later, they fight with the spy-'ssassins, but Jerry's arrival causes an avalanche. The moms are safe, however, the girls have gone missing.