The night shift at San Antonio Memorial Hospital is when all the toughest and craziest cases come through the door. With the cash-strapped facility now under his control, hospital administrator Michael Ragosa is determined to keep things running even if it means making financial decisions that clash with his headstrong staff. That’s especially true of Dr. TC Callahan, a brilliant,...

When deputy Nick Woods is shot, TC vows to do everything he can to save him, especially since Woods is alive thanks to a heart transplant from TC's brother when they were fighting in Afghanistan. Refusing to give up despite the seriousness of Nick's wounds, TC summons the surgeon who performed the first transplant, Dr. Flannery Mills, to repair his damaged heart. However, when Ragosa objects...

While Drew hides the injuries he sustained during an Army vs. Air Force mixed martial arts fight, TC and Paul head for a feral hog hunt where a woman named Amy was shot with an arrow and her brother-in-law Henry lost his hand to a wild boar. As the chaotic hunt sparks traumatic wartime memories, TC realizes that reattaching Henry's severed hand means retrieving it from the stomach of the wild...

The annual re-enactment of the Battle of the Alamo has swamped the ER with injured combatants, including an unidentified man with a gunshot wound in his leg. When told he's a Christian Scientist, Jordan ignores his "do not treat" directive to save his leg. However, when a paramedic tips Ragosa off, he suspends Jordan until the hospital's lawyers question her. Because the suspension has left TC...

As Ragosa urges Jordan's boyfriend, Dr. Scott Clemmens, to head up the Trauma Department at San Antonio Memorial, a series of devastating storms overwhelms the hospital with injuries. With the ER suddenly shorthanded, Scott pitches in to help TC rescue Shannon Mulroney and her seven-year-old son, Ernie, from a mudslide that's destroyed their mobile home. As power outages threaten to shut down...

As TC and Jordan rekindle their still-smoldering relationship, ambulances start arriving at SAMH with soldiers just back from Afghanistan who’ve been injured in a bus accident – including Drew's boyfriend, Captain Rick Lincoln. After they are interrupted by an emergency call, TC and Jordan arrive at the hospital together, a fact that doesn’t escape Scott. With Rick in danger of losing his leg,...

When a small plane goes down in a remote canyon, TC and Topher rappel from the helicopter into the crash site. Finding the pilot dead, they turn their attention to his passenger, Eric, who is carrying a load of heroin. So when DEA agent Milo Osborne intercepts them upon their arrival at the hospital, he demands to question Eric as soon as possible. After an exotic dancer named Candy is...

As victims from a factory explosion overwhelm the ER, the shooting in the radiology lab has TC and Jordan focused on saving Topher's life. Though Jordan would prefer letting the drug dealer who shot Dwayne and Topher die, Ragosa insists he be treated like any other patient. So when the detective investigating the case worries that there’s no one available to operate when Milo needs surgery,...