Supernatural

In the tenth season premiere, Dean (JENSEN ACKLES) is living it up as a demon and running amok with Crowley, while Sam hits rock bottom in the search for his brother.

As Dean becomes more aggressive, Crowley tells him that the Mark of Cain needs to be fed. Meanwhile Sam is captured by Cole, who wants revenge on Dean for his father's murder.

While Sam tries to save Dean from the Mark of Cain, Crowley realizes that Dean's demonic antics are causing problems for him in Hell, so he asks for help...from Castiel.

A recent string of werewolf attacks points to a surprising culprit - Kate (guest star BRIT SHERIDAN), the werewolf Sam and Dean let live.

In the 200th episode, Sam and Dean investigate the disappearance of a teacher, but are stunned to discover that the school is putting on a musical based on their lives.

Sam and Dean get a surprising message from Bobby's cell phone when they learns that Bobby's next of kin has been named as a beneficiary in an heiress's will.

Stumbling upon a demon running from Crowley, Sam & Dean encounter Rowena (recurring guest star RUTH CONNELL), who's recruiting followers in the art of witchcraft.

Sheriff Jody Mills (recurring guest star KIM RHODES) returns, when she calls Sam and Dean to investigate a body that's been stripped of flesh.

Castiel (MISHA COLLINS) is reunited with the daughter of his vessel who asks for his help in breaking her out of a group home. Meanwhile, Crowley faces his biggest challenge yet.

In the aftermath of the massacre, Dean, Sam and Castiel double their efforts to find a cure for the Mark of Cain - but there is nothing in the lore that can help them.

When Sam and Dean discover that Charlie Bradbury (recurring guest star FELICIA DAY) has returned from Oz, they're shocked to learn the reasons why she's become a vicious killer.

Dean is turned into his 14-year-old self when Hansel (from Hansel & Gretel lore) kidnaps victims and converts them into children to placate the evil witch (LESLEY NICOL).

Sam and Dean discover a ghost seeking revenge on a group of college students, but they can't figure out how he's doing it through various electronic devices.

Sam, Dean and Castiel deal with the return of Cain (TIMOTHY OMUNDSON), but when Crowley offers to help, his mother lets him have it.

Cole (recurring guest star TRAVIS AARON WADE) teams up with the Winchesters on a murder case in which a Khan worm is infecting its victims and turning them into murderers.

When Crowley captures Olivette (guest star TERYL ROTHERY), the leader of the Grand Coven, Rowena pleads her case to be allowed to practice magic freely again.

While Sam and Castiel follow up on a lead about the Mark of Cain, Dean and Rowena face off against each other.

Charlie Bradbury calls Sam & Dean to tell them she found the Book of the Dead, which might help remove the Mark of Cain. Castiel & Metratron (CURTIS ARMSTRONG) take a road trip.

Sam sets out to find a magical box built by the former Man of Letters Magnus in the hopes that it can cure Dean of the Mark of Cain.

When Claire Novak gets a lead on her missing mother, Castiel asks Sam and Dean to help, but there is a chance Claire may not get her happy ending.

Investigating a bizarre murder, Sam and Dean meet up with the Styne family again. Meanwhile, Charlie and Rowena must work together on the Book of the Damned.

When it comes to the Stynes, Dean decides to take matters into his own hands, while Sam tries to come to terms with his decision.

In the season finale, Dean makes a shocking decision about the Mark of Cain with repercussions for both he and Sam. Meanwhile, Crowley and Rowena face off.