I den første sesongen, ti komikere: Silvia Abril, Edu Soto, Yolanda Ramos, Mario Vaquerizo, El Monaguillo, David Fernández, Arévalo, Rossy de Palma, Paco Collado og Carolina Noriega kjemper i seks timer på rad for å unngå å trekke en mine, samtidig som de prøver å få motstanderne til å le. Konkurransen overvåkes av en fantastisk vert, Santiago Segura, med hjelp fra med-vert Xavier Deltell.

Santiago Segura and his minion Deltell have kidnapped ten comedians to perform a crazy experiment. At the end, only one will remain.

Santiago surprises the comedians with an assignment that will bring about the first card for one of the favorites. A second ejection and three yellow cards will force the contestants to roll up their sleeves.

After two hours and five yellow cards, the comedians bring out their best weapons. Finally, a third contestant must leave the game.

It’s time to go all out to knock down their rivals. And they don’t disappoint… The competition is now down to five.

With only two hours left on the clock, the comedians have apparently lost their minds. A new ejection leaves only four contestants to face the last hour of the game.

A double ejection means there are only two contestants left in the game. In a final push, they challenge each other, trying to make their rival crack. After an intense duel, one of them will be declared the first winner on LOL “If you laugh, you lose”.