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As Danny consults a psychic to solve the murder of a young boy, Frank is at odds with the mayor over how best to protect the city from an uptick in crime following a high-profile shooting.

Tension escalates between Frank and Mayor Chase (Dylan Walsh) after Frank makes a public arrest that goes viral. Also, Danny and Baez investigate a gang attack that takes an unexpected turn.

Frank must decide between remaining police commissioner and pursuing a new professional chapter when his old friend Lenny Ross (Treat Williams) presents him with an exciting job offer.

Jamie faces backlash from fellow officers, when he partners with Erin and Anthony to investigate an underground bar the NYPD and FDNY use to hide their criminal indiscretions. Also, Eddie's partner, Witten, considers leaving the force.

Jamie and Eddie experience marital tension when Eddie allows her newly released ex-convict father, Armin, to live with them. Also, Danny and Baez go out of their way to help a desperate out-of-town man find his missing sister.

Frank causes family tension when he assigns Jamie to guard Danny after a hit is put on him, and when Frank tries to stop his cop grandson, Joe Hill (Will Hochman), from seeking revenge after he's attacked.

Danny and Baez's attempts to find the culprit who assaulted a shop owner are hindered by the close-knit community's refusal to cooperate with the investigation.

Danny partners with Anthony to solve a double homicide when Anthony's shady cousin, Joey, proves to have gang ties to the crime. Also, the boundary between Eddie and Jamie's work and personal relationship is strained.

Frank enlists the help of an old friend, Sloane Thompson (Alex Kingston), to investigate a cyber-attack on the NYPD that forces Danny and Baez to release an evasive suspect. Also, Baez questions her place within the NYPD.

An illegal drug shipment arriving in New York City forces Danny to partner up with his Texas Ranger associate, Major Waylon Gates (Lyle Lovett), to find the narcotics before they flood the streets.

Danny pursues Dickie Delaney (Jimmy Buffett), a con artist pretending to be the legendary singer Jimmy Buffett, after he's tricked into paying for the scammer's meal at an expensive restaurant.

Frank is at odds with his friend Archbishop Kearns when he says the NYPD arrested the wrong man for a murder, but he can't break the confessional seal to reveal the true killer's identity.

Frank contends with a potentially dirty cop within his ranks when Danny and Baez's investigation into a brutal assault on an NYPD detective reveals the officer may be corrupt.

Erin and Anthony team up with Erin's nephew, police officer Joe Hill (Will Hochman), to course-correct a trial when Joe becomes aware of witness tampering.

Frank contends with public outcry to defund the NYPD School Safety Division, after a physical altercation between a school officer and a student goes viral.

Frank, Baker, Garrett and Gormley experience feelings of guilt when Detective Angela Reddick, an officer they briefly worked with at 1PP, is shot after Frank reassigned her for not meshing with their team.

Frank is blindsided when Mayor Chase bypasses him with a request for Jamie to head his security detail. Also, Danny and Baez investigate the murder of a wealthy college student.

Frank faces a dilemma when a Marine veteran, who became a local celebrity for saving a woman's life, asks him to make an exception to the NYPD recruitment age limit so he can join the force.

When Erin is stalked by a man who was recently released from prison after serving 12 years, she enlists Anthony and Danny to investigate her office's role in his sentencing.

Danny and Jamie join forces with their nephew, Joe Hill, when Jamie and Joe's search for an undocumented teenage girl who has been sex-trafficked, converges with Danny and Baez's investigation into the murder of a woman in witness protection.