As Captain Elizabeth Lochley takes command of Babylon 5, Sheridan is inaugurated as president of the InterStellar Alliance. A telepath thwarts an assassination attempt on Sheridan.

During a heart attack, Londo experiences an epiphany and apologizes to G'Kar. Lennier surprises Delenn with unwelcome news: he is quitting as her aide.

Military crises threaten the ongoing formation of the InterStellar Alliance, but Sheridan asserts its power. Sheridan wants to use the telepaths for information gathering.

An alien attack on Babylon 5 is viewed from the perspective of two lowly maintenance workers.

Delenn receives an update from the Rangers on Minbar. A ranger-in-training visits Babylon 5 and fights a criminal. Lochley reveals some secrets — including the fact that she fought with the corrupt Earth government against Sheridan in the recent war.

The secret of Sheridan and Lochley's past marriage is revealed. Psi Corps cop Bester tracks down the rogue telepaths. Londo's life is endangered, and G'Kar is assigned as Londo's bodyguard.

A telepath is assaulted, and the others vow revenge. The Hyach are hiding their medical history, and Dr. Franklin tries to find out why.

A comedy team visits Babylon 5. During a macabre alien celebration, station residents meet spirits of the dead.

Byron and other telepaths seek a homeworld of their own. On Centauri Prime, Londo's friend is murdered, and Londo fears for his own life.

Lochley asks Bester for help with a group of telepaths who have locked themselves in Downbelow. The telepath resistance turns violent. Alliance members accuse each other of recent shipping attacks. G'Kar finds his former aide in a Centauri prison.

The fight with Byron's followers gains intensity. Garibaldi and Dr. Franklin are inside the medlab when it is seized. The telepath crisis eventually comes to a horrific end, and Garibaldi swears a personal vendetta on Bester.

Garibaldi is sent to retrieve a witness to the shipping line attacks from the Drazi homeworld. G'Kar returns to the station and finds he is a revered religious figure after his book is published.

While tracking an unstable telepath trainee on Babylon 5, Bester instructs two interns on the motives of the Psi Corps.

Vir learns he is the new Centauri ambassador to Babylon 5. Lennier travels to the Centauri border for evidence linking them to the attacks on shipping lines. Sheridan attempts to preserve peace among the agitated Alliance members.

Lennier's discovery of the Centauri's involvement in the shipping line attacks promises to cause all-out war. Lyta makes a deal with G'Kar to find a home for the telepaths. Garibaldi's alcoholism worsens.

Sheridan announces the Centauris' guilt. After a boycott is issued against them, they recede from the alliance and threaten to use force. Londo finds trouble when he returns home with G'Kar. Garibaldi takes on an awesome responsibility.

The seemingly purposeless Centauri attacks culminate in a bizarre and terrifying climax. The White Star fleet joins the war, while Minbari decides to help Earth build a destroyer-class ship.

Londo discovers that the Drakhs are really behind the war, planning to alienate the Centauris from the alliance. He also learns his fate. Sheridan searches for Delenn's lost ship.

Lyta is arrested for terrorism, while the number of G'Kar's worshippers begins to grow. Garibaldi makes a decision after Sheridan confronts him about his alcoholism.

Lise and Michael learn they are the targets of an assassin. G'Kar prepares to leave.

The end of 2262 brings many changes to Babylon 5. Amidst farewells and new beginnings, disaster occurs as Sheridan and Delenn travel to their new home, Minbar, where the alliance headquarters is located.

Twenty years after the formation of the InterStellar Alliance, Sheridan summons his dearest surviving friends for a bittersweet reunion.