In the final season premiere, Sam (JARED PADALECKI), Dean (JENSEN ACKLES) and Castiel are left to defend the world after all the souls in Hell have been released back on Earth.

Sam, Dean and Castiel call on Rowena (RUTH CONNELL) to help keep the evil souls at bay, and get an unexpected assist from Ketch (DAVID HAYDN-JONES).

Together with Rowena, Sam and Dean work tirelessly to keep all of hell from breaking loose. Meanwhile, Castiel cannot forgive an arrogant betrayal.

Sam and Dean investigate the mysterious death of a girl and the disappearance of another. Series star JENSEN ACKLES directed the episode.

Sam and Dean's routine case turns out to be anything but. Recurring guest star RICHARD SPEIGHT, JR. directed the episode.

While Castiel investigates the disappearance of a local teen, Sam and Dean are visited by an old friend.

Dean goes off on his own to take on a case. Meanwhile, Castiel has an idea of how he can help Sam track down God.

Sam, Dean and Castiel's continued search for a way to defeat Chuck (ROB BENEDICT) leads them to unexpected places and toward unlikely allies.

While Sam and Eileen (guest star SHOSHANNA STERN) face the brutal truth, Dean and Cas work together to get a step ahead of Chuck.

Sam and Dean hit the road to help an old friend, but it appears that their luck may have finally run out when they are the ones who may be in need of rescue.

Sam and Dean press their luck in a winner-takes-all game of pool. Meanwhile, Castiel hunts down a would-be murderer, but not for reasons one might think.

Sam & Dean – along with Castiel, Jack & Jody Mills – assist in an extraordinary and heartbreaking rescue. Billie surprises everyone at the bunker.

A search for the one thing that may give them an edge against God leads Sam & Dean to Jo's (DANNEEL ACKLES) door and to a secret that may have died with Ruby (GENEVIEVE PADALECKI).

Sam and Dean discover a wood nymph (guest star MEAGEN FAY) living in the bunker who's determined to protect her family at any cost.

While Sam and Dean go off in search of Amara (guest star EMILY SWALLOW), Castiel and Jack work a case involving members of a local church.

Investigating the murder of a childhood friend, Sam & Dean are called back to a motel from their past and a case they thought was solved a long time ago.

Dean hits the road with Jack, who needs to complete a final ritual in the quest to beat Chuck. Meanwhile, a difference of opinion leaves Sam and Castiel behind looking for answers to questions of their own.

With the plan in full motion, Sam, Dean, Castiel and Jack fight for the good of the common goal.

With everything on the line as the battle against God continues, a familiar face returns to join the fight.

After 15 seasons, the longest running sci fi series in the U.S. is coming to an end. Baby, it's the final ride for saving people and hunting things.

In this celebratory episode, get ready for the series finale with cast interviews from Jared Padalecki, Jensen Ackles, Misha Collins and Alexander Calvert with series creator Eric Kripke, executive producers Robert Singer and Andrew Dabb and special guest stars Jim Beaver, SAMANTHA SMITH, Ruth Connell, Kim Rhodes and MARK SHEPPARD.