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Erin's case against cartel member Carlos Munoz intersects with a husband-and-wife domestic abuse call that Jamie handled, but when the wife is murdered all hands are on deck, the husband becomes the prime suspect.

Danny and Baez respond to a call that their psychic friend, Maggie Gibson, has been stabbed.

Suspicion is high when Danny and Baez respond to a call from hotel housekeepers who found a large blood stain on a mattress with no sheets or towels in the room.

Danny and Baez investigate a series of violent robberies targeting luxury timepieces, and Erin is conflicted about criminally charging a potentially innocent man.

Frank launches an investigation after the Reagan family is harassed when protests against a controversial NYPD unit escalate. Also, Danny and Baez form an unlikely partnership with an informant in order to prevent a murder.

Danny and Jamie clash over a gang-related shooting after Jamie oversteps as part of his new position and Danny empathizes too closely with a victim.

Erin and Anthony clash when Anthony's daughter, Sophia, is the sole eyewitness to a fatal shooting.

Danny crosses paths with Sonny Le (Alex Duong), a criminal from a previous case, when he investigates a gang attack with a shocking motive.

Reagan family tensions run high when Frank and his grandson, Joe Hill (Will Hochman), contend with a grievous insult to the memory of Joe's father, Joe Reagan.

Jamie and his new intel team officer infiltrate a high-tech car smuggling ring. Also, Frank faces off against the city's transit chief over a new mayoral solo police patrol program that is causing officer injuries on the job.

Danny and Baez's investigation into the death of a chess hustler is complicated by interference from the victim's son. Also, Erin is offered an endorsement of her run for D.A. by an influential Harlem pastor in exchange for a professional favor.

Danny reunites with Mickey Patrick (Tom Cavanagh), his childhood friend and a former criminal, who comes to him for help finding his missing fiancée. Also, Anthony surprises Erin with one last stakeout before her run for district attorney.

Danny and Baez race against the clock to catch a serial killer targeting young women across the city. Also, Erin and Eddie clash when Eddie intervenes in a murder case and Erin's personal life.

The return of Rachel Witten (Lauren Patten), Eddie's former partner turned social worker, tests her loyalties and conflicts Frank, when Rachel brings an accusation of excessive force against an officer.

Danny partners with Texas Ranger Waylon Gates (Lyle Lovett) again to deliver an infamous drug cartel boss to arraignment, but the mission becomes complicated when the criminal threatens to harm the Reagans.

Jamie and Eddie find themselves at odds when Jamie learns that Eddie's close friend Tracey (Alysha Umphress) may be using the restaurant she owns as a drug front. Also, Erin forms an alliance with Anthony and her ex-husband, Jack Boyle.

Frank clashes with the Dream Team when one of the members becomes the focus of a departmental investigation. Also, Jamie and Danny team up to investigate a series of carjackings involving one of Danny's criminal informants.

Danny and Baez investigate a case of grand larceny tied to feuding crime families when the gifts are stolen during a mob wedding. Also, Frank clashes with Mayor Chase (Dylan Walsh) when an influx of immigrants arrive in the city.

Jamie partners with the FDNY to find the arsonist responsible for a massive fire at an NYPD evidence storage facility.

Frank worries about his longtime friend Lenny Ross (Treat Williams) when he suspects the former officer is hiding his true reason for returning to the city.

Danny (Donny Wahlberg) and Baez (Marissa Ramirez) team up with Danny's old partner, Jackie Curatola (Jennifer Esposito), to find a copycat killer emulating a criminal's murders from a previous case.