The 4400

A high school student develops an ability after injecting promicin. Tom visits Isabelle in jail, while Diana searches for her missing sister. Following the advice of a young woman named Cassie, Kyle is able to wake Shawn from his coma.

Tom and Diana search for a person who has the ability to make people's worst fears come to life. Danny seeks Shawn's help in finding a promicin shot. Cassie leads Kyle to a book that contains a prophecy about Jordan Collier.

Audrey Parker develops the ability to astral project herself. However, after she is murdered, Audrey attempts to use her ability to lead Tom and Diana to her killer.

April's new ability endangers her life. Shawn is approached to run for public office, while Kyle helps Isabelle.

After realizing Tom knows he is promicin-positive, Kyle joins Jordan in a remote town called Evanston. Tom follows Kyle, and learns the remarkable truth about Evanston: all of its residents are promicin-positive.

Tom and Diana search for Curtis Peck, a 4400 film maker whose ability allows him to 'know' the truth behind historical conspiracies. Jordan tries to recruit Shawn into his movement.

Jordan and his followers annex a run-down part of Seattle, dubbing it 'Promise City'. Shawn's campaign for city council is threatened when a woman accuses him of using his healing ability in exchange for sex.

A lockdown at NTAC threatens the lives of Tom, Diana, Meghan, Shawn, Kyle, Jordan, Isabelle, Maia, Marco, PJ and Brady when they wakeup inside the building with no recollection of how they got there.

Richard kidnaps Isabelle from Collier's Promise City. Richard hopes to start a new life with his daughter. Elsewhere, Tess has taken over a 1950's diner, and Shawn is asked to intervene.

The Director of National Intelligence pressures NTAC to pursue Richard and Isabelle. Richard is visited by his dead wife, Lily.

A computer virus attacks a large software company owned by a suspected member of The Marked. Maia visits Promise City and receives an unexpected birthday gift.

Isabelle works with Tom in order to get close to Jordan. Shawn recruits a small band of promicin positives to break Kevin out of Promise City. Tom and Diana face off in the backroom of a grocery store, and Diana is forced to shoot Tom.

Danny Farrell's newfound ability to spread promicin leads to several hundred deaths, including his mother. With Seattle in chaos, NTAC is forced to accept Promise City's offer of help.